• If you need to source various services around drug discovery and development, TOXPeer can provide value added inputs from world class experts in number of therapeutic areas i.e. metabolic disorders, pain, inflammation, cancer etc.
• Team TOXPeer has expertise in the areas of biocide research, identifying secondary metabolites, residue chemistry etc., to support Agro-industry for safer pesticide.
• TOXPeer can help you to identify the right partner in India or West, be it simple outsourced work or through strategic partnership.
• Out-licensing processes like identifying partners, evaluation of projects, due-diligence, negotiations etc. can be done by the team of TOXPeer experts.

Consulting Services

Integrated Drug Discovery and Development

TOXPeer scientists have drug discovery and development experience across a range of therapeutic areas with an emphasis on Oncology, CNS, Metabolic Disorder, Cardiovascular, Respiratory Disease, Inflammation, Infectious, and Rare Diseases and also maintain close links with key opinion leaders and regulators. Support all aspects of early discovery, including:

• Conceptualize, and evaluate drug targets
• Assay development
• High-throughput screening (HTS)
• Hit identification and hit-to-lead to lead-optimization
• PK-PD
• Identification of Biomarker
• Mechanism of action
• Combination Studies
• DMPK
• Non-GLP and GLP Toxicology
• IND filing

Biology

Our biologists provide solutions for molecular biology, biochemistry, cell biology and in vivo biology:

• Evaluation of drug targets
• Establishment of screening cascade
• Mechanism of action
• Identification of biomarkers
• Combination studies
• Efficient experimental design and data collection to qualify leads and clinical candidates

Medicinal Chemistry

Our Medicinal Chemistry specialists, with both biotech and large pharma industry experience, can guide delivery of leads/clinical candidates in major therapeutic areas. We offer:

• Rational Drug Design
• IP Generation
• Multi-Dimensional Optimization (MDO)
• X-ray crystallography

Synthetic Chemistry

Provide solutions for synthetic routes

ADME

TOXPeer ADME group is dedicated to providing quality services to the pharmaceutical and biotechnology industries in a timely and cost-effective manner and offer a full range of services in India and USA enabling our clients to resolve the absorption, distribution, metabolism, and excretion related issues of their compounds translating preclinical information to clinical trials.

Toxicology

TOXPeer experts with years of industry experience providing design, implementation, and management of nonclinical testing programs with a focus on company goals:

General Toxicology:

• Nonclinical overviews, interpretation, and positioning of data (toxicology study reports, literature, safety data)
• Toxicological Risk Assessments for Impurities, Leachables & Extractables
• Determination of Permitted Daily Exposure (PDE) and Occupational Exposure Limits
• Environmental Risk Assessments
• Gap analysis and independent data reviews
• GLP study monitoring, including pre-placement and in-life study audits 

Pathology:

• Toxicologic pathology for repeat-dose studies
• Pathology peer reviews
• Discovery pathology and characterization of disease models
• Pathology expert statements

Infrastructure Setup

TOXPeer scientists have wide experience of setting up research and development facilities:

• Integrated drug discovery and development centre including biology, chemistry, DMPK, Toxicology and translational labs
• Animal house with AAALAC accreditations
• GLP Toxicology facilities in developing countries as per international standards.

GLP and accreditation require extensive paper work, facility modification, validation, training and regulatory guidance.

Outsourcing Services

TOXPeer can help you fulfilling your outsourcing needs around drug discovery and development:

Biology

• siRNA
• Gene cloning, protein expression and purification
• Biochemical & Cell based assay development
• Screening
• Biomarkers
• PK-PD
• Efficacy in multiple models
• Immunoassays

Chemistry Syntheses

• Designing of chemical scaffold
• Custom syntheses

Preclinical and clinical DMPK

• Bio analytical method development and validation
• Metabolite identification
• PK and TK in rodent/non-rodents
• Mass balance studies
• Plasma protein binding
• Metabolic stability
• Permeability studies
• Assessment of physicochemical & In vitro ADME properties
• PK/PD

Preclinical Toxicology and Safety Pharmacology

General Toxicity studies:

Acute toxicity studies in Rats and mice, MTD studies in rat and mice with TK, Dose escalation and range-finding, Non-GLP 4, 7 and 14 day toxicity studies in rat and mice with TK, Sub-chronic & Chronic GLP Toxicity studies

Genotoxicity studies:

Ames test, Chromosomal Aberration test (in vitro & in vivo), Micronucleus test (in vitro & in vivo)

Safety Pharmacology studies:

CNS safety, CVS safety (hERG patch clamp & Dog telemetry) and Respiratory safety

API Manufacturing and Control

API experts at TOXPeer have the list of API manufacturer of national and international reputes having state-of-the art GMP facilities to support scale-ups and bulk productions with the best suited chemical processes to speed up your business.